| | Date | Opponent | | Score | | | Overall | Conference | Attend | Goals scored |
| | Aug 20, 2010 | RICE | W | 1-0 | | | 1-0-0 | 0-0-0 | 518 | Mullins, Georgia (unassisted) |
| | Aug 22, 2010 | MCNEESE STATE | W | 7-0 | | | 2-0-0 | 0-0-0 | 324 | Clark, Christine (Polley, Selby) |
| | | | | | | | | | | Larsen, Dana (Gilmore, Hanna) |
| | | | | | | | | | | Gilmore, Hanna (Sliwinski, Lisa) |
| | | | | | | | | | | Gilmore, Hanna (Sliwinski, Lisa) |
| | | | | | | | | | | Polley, Selby (Ludlow, Kat) |
| | | | | | | | | | | Ludlow, Kat (Moran, Allie) |
| | | | | | | | | | | Hagen, Michelle (Summey, Karlee) |
| | Aug 27, 2010 | HOUSTON BAPTIST | W | 6-0 | | | 3-0-0 | 0-0-0 | 418 | Gilmore, Hanna (Larsen, Dana) |
| | | | | | | | | | | Smith, Lotto (Johnson, Lindsey) |
| | | | | | | | | | | Sliwinski, Lisa (Dismuke, Hannah) |
| | | | | | | | | | | Gilmore, Hanna (Hunemuller, Brittany) |
| | | | | | | | | | | Sliwinski, Lisa (Davis, Carlie) |
| | | | | | | | | | | Sliwinski, Lisa (Hunemuller, Brittany) |
| | Aug 29, 2010 | at Arizona State | | 1-3 | L | | 3-1-0 | 0-0-0 | 318 | Salinas, Staz (Dismuke, Hannah) |
| | Sep 03, 2010 | UTSA | W | 4-0 | | | 4-1-0 | 0-0-0 | 458 | Gilmore, Hanna (Larsen, Dana) |
| | | | | | | | | | | Sliwinski, Lisa (Smith, Lotto) |
| | | | | | | | | | | Hunemuller, Brittany (Smith, Lotto) |
| | | | | | | | | | | Johnston, Bethany (Clark, Christine) |
| | Sep 05, 2010 | HOUSTON | W | 1-0 | | | 5-1-0 | 0-0-0 | 302 | Sliwinski, Lisa (Gilmore, Hanna) |
| | Sep 10, 2010 | NEW MEXICO | | 0-0 | T | O2 | 5-1-1 | 0-0-0 | 471 | - |
| | Sept 17,2010 | at Sam Houston State | W | 2-0 | | | 6-1-1 | 0-0-0 | 121 | Summey, Karlee (Gilmore, Hanna) |
| | | | | | | | | | | Larsen, Dana (Johnson, Lindsey) |
| | Sep 19, 2010 | PRAIRIE VIEW A&M | W | 9-0 | | | 7-1-1 | 0-0-0 | 308 | Polley, Selby (Klein, Alex) |
| | | | | | | | | | | Smith, Lotto (Sliwinski, Lisa) |
| | | | | | | | | | | Smith, Lotto (Clark, Christine) |
| | | | | | | | | | | Larsen, Dana (Smith, Lotto) |
| | | | | | | | | | | Larsen, Dana (Sliwinski, Lisa) |
| | | | | | | | | | | Sliwinski, Lisa (Dismuke, Hannah) |
| | | | | | | | | | | Mauk, Andrea (unassisted) |
| | | | | | | | | | | Hoffman, Vic (unassisted) |
| | | | | | | | | | | Summey, Karlee (Kloss, Michelle) |
| * | Sep 24, 2010 | at #12 Oklahoma State | | 1-2 | L | | 7-2-1 | 0-1-0 | 809 | Larsen, Dana (unassisted) |
| * | Sep 26, 2010 | at Oklahoma | | 2-3 | L | | 7-3-1 | 0-2-0 | 516 | Johnston, Bethany (unassisted) |
| | | | | | | | | | | Sliwinski, Lisa (unassisted) |
| * | Oct 01, 2010 | NEBRASKA | W | 2-1 | | | 8-3-1 | 1-2-0 | 514 | Klein, Alex (Hoffman, Vic) |
| | | | | | | | | | | Clark, Christine (unassisted) |
| * | Oct 03, 2010 | #22 COLORADO | W | 1-0 | | O2 | 9-3-1 | 2-2-0 | 302 | Larsen, Dana (Sliwinski, Lisa) |
| * | Oct 08, 2010 | at #10 Texas A&M | | 0-2 | L | | 9-4-1 | 2-3-0 | 2202 | - |
| * | Oct 10, 2010 | at Texas | | 0-1 | L | | 9-5-1 | 2-4-0 | 593 | - |
| | Oct 15, 2010 | SEATTLE | | 1-1 | T | O2 | 9-5-2 | 2-4-0 | 202 | Gilmore, Hanna (penalty kick) |
| * | Oct 17, 2010 | at Kansas | W | 1-0 | | O2 | 10-5-2 | 3-4-0 | 589 | Gilmore, Hanna (penalty kick) |
| * | Oct 22, 2010 | MISSOURI | | 0-2 | L | | 10-6-2 | 3-5-0 | 581 | - |
| * | Oct 24, 2010 | IOWA STATE | | 0-1 | L | | 10-7-2 | 3-6-0 | 401 | - |
| * | Oct 29, 2010 | TEXAS TECH | W | 1-0 | | | 11-7-2 | 4-6-0 | 419 | Clark, Christine (unassisted) |
