| 08/19/2021 | at Minnesota | L | 0-1 | 0-0-0, 0-0-0 | 0-0-0 | 512 | |
| 08/22/2021 | at North Dakota State | W | 4-0 | 1-1-0, 0-0-0 | 0-0-0 | 170 | Maddie Algya (1) (Taylor Moon , Gabby Mueller) Taylor Moon (1) (Gabby Mueller) Ally Henderson (1) Mackenzie Anthony (1) (Elizabeth Kooiman)
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| 08/26/2021 | vs Nebraska | L | 1-2 | 1-2-0, 0-0-0 | 0-0-0 | 930 | Gabby Mueller (1) (Mackenzie Anthony)
|
| 08/29/2021 | vs SMU | W | 2-1 | 2-2-0, 0-0-0 | 0-0-0 | 297 | Mackenzie Anthony (2) (Ally Henderson) Haven Terry (1) (Lorelai Stramrood , Jennifer Wandt)
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| 09/02/2021 | at North Texas | W | 2-0 | 3-2-0, 0-0-0 | 0-0-0 | 574 | Maddie Algya (1) Mackenzie Anthony (3)
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| 09/05/2021 | at Wisconsin | T | 0-0 | 3-2-1, 0-0-0 | 0-0-0 | 1171 | |
| 09/12/2021 | vs Oregon | T | 2-2 | 3-2-2, 0-0-0 | 0-0-0 | 354 | Mackenzie Anthony (4) (Elizabeth Kooiman) Chloe Japic (1)
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| 09/16/2021 | vs SFA | W | 3-0 | 4-2-2, 0-0-0 | 0-0-0 | 340 | Mackenzie Anthony (5) (Haven Terry , Elizabeth Kooiman) Chloe Japic (2) (Maddie Algya) Elizabeth Kooiman (1) (Ally Henderson)
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| 09/19/2021 | vs San Francisco | T | 1-1 | 4-2-3, 0-0-0 | 0-0-0 | 248 | Mackenzie Anthony (6) (Taylor Moon)
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| 09/23/2021 | at Oklahoma St. | W | 2-1 | 5-2-3, 1-0-0 | 1-0-0 | 662 | Taylor Moon (2) (Mackenzie Anthony) Olivia Mack (1) (Jennifer Wandt , Lorelai Stramrood)
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| 09/26/2021 | at TCU | W | 2-1 | 6-2-3, 2-0-0 | 2-0-0 | 1413 | Taylor Moon (3) (Maddie Algya) Elizabeth Kooiman (2)
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| 09/30/2021 | vs Texas Tech | W | 3-2 | 7-2-3, 3-0-0 | 3-0-0 | 488 | Taylor Moon (4) (Elizabeth Kooiman) Olivia Mack (2) (Mackenzie Anthony) Gabby Mueller (2)
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| 10/07/2021 | at Kansas | L | 1-2 | 7-3-3, 3-1-0 | 3-1-0 | 626 | Kayley Ables (1) (Gabby Mueller)
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| 10/10/2021 | at Kansas St. | T | 0-0 | 7-3-4, 3-1-1 | 3-1-1 | 945 | |
| 10/15/2021 | vs Texas | T | 0-0 | 7-3-5, 3-1-2 | 3-1-2 | 1010 | |
| 10/21/2021 | vs Iowa St. | W | 2-0 | 8-3-5, 4-1-2 | 4-1-2 | 304 | Mackenzie Anthony (8) Mackenzie Anthony (8) (Elizabeth Kooiman)
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| 10/24/2021 | vs West Virginia | T | 0-0 | 8-3-6, 4-1-3 | 4-1-3 | 464 | |
| 10/28/2021 | at Oklahoma | L | 0-2 | 8-4-6, 4-2-3 | 4-2-3 | 429 | |
| 10/31/2021 | vs West Virginia | L | 0-1 | 8-5-6, 4-2-3 | 4-2-3 | 0 | |